Curcumin - turmeric pigment
is Antiviral-tumor ...
The curcumin or diféruloylméthane is the main pigment turmeric (Curcuma longa)
Turmeric present in all good cooking!
Curcumin is a powerful antioxidant more active than vitamin E, a powerful antiseptic and antibacterial, and a powerful anti-inflammatory as it inhibits Cyclooxygenase 2 and the transcription factor NF kappa B involved in inflammatory processes.
All tests have been conducted on humans with curcumin, have shown that when used alone, curcumin is rapidly eliminated by the organism.
Piperine (present in black pepper) is capable of inhibiting the elimination pathways of curcumin, and thus increase its bioavailability by a factor of 20.
extracts of turmeric curcumin are highly concentrated in some cases also associated with the pepper piperine to improve the bioavailability of curcumin and are offered as a dietary supplement to help protect general cellular or physiological situations of joint discomfort .
http://fr.wikipedia.org/wiki/Curcumine
Laboratory studies had already shown that curcumin might stimulate the body's ability to destroy the building of plaques in the brain related to Alzheimer's .
Researchers at the University of Singapore have recruited 1010 subjects aged Asian, then compared their scores to assess their mental state and have been in touch with their frequency of consumption of curry.
They found that subjects consuming curry often or very often were 49% lower risk of cognitive impairment than those who rarely or never took.
Add to this the fact that the prevalence of Alzheimer's disease in people aged 70 to 79 years is four times lower in India than the United States.
______________________________Department of Pharmacology, St. John's Medical College, Bangalore, India.
The medicinal properties of curcumin obtained from Curcuma longa L. cannot be utilised because of poor bioavailability due to its rapid etabolism in the liver and intestinal wall.
In this study, the effect of combining iperine, a known inhibitor of hepatic and intestinal glucuronidation, was evaluated on the bioavailability of curcumin in rats and healthy human volunteers.
When curcumin was given alone, in the dose 2 g/kg to rats, moderate serum concentrations were achieved over a period of 4 h. Concomitant administration of piperine 20 mg/kg increased the serum concentration of curcumin for a short period of 1-2 h post drug.
Time to maximum was significantly increased (P < 0.02) while elimination half life and clearance significantly decreased (P < 0.02), and the bioavailability was increased by 154%.
On the other hand in humans after a dose of 2 g curcumin alone, serum levels were either undetectable or very low.
Concomitant administration of piperine 20 mg produced much higher concentrations from 0.25 to 1 h post drug (P < 0.01 at 0.25 and 0.5 h; P < 0.001 at 1 h), the increase in bioavailability was 2000%.
The study shows that in the dosages used, piperine enhances the serum concentration, extent of absorption and bioavailability of Both curcumin in rats and Humans With No adverse effects.
PMID: 9619120 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/pubmed/9619120 _________________________________Curcumin stimulates
liver detoxification capacity
curcumin extracted from turmeric, is a powerful antioxidant that provides protection against damage caused by free radicals.
In 1995, scientific studies have shown that a diet containing curcumin reduced oxidative stress. During an investigation, researchers found that curcumin decreased the oxidative stress induced by trichlorethylene in the liver of mice.
They concluded that the beneficial effects of curcumin appeared to derive from its ability to curb the increase in cellular levels of peroxisome, a component associated with the use of oxygen by cells.
In addition to the direct antioxidant, curcumin stimulates the synthesis of glutathione. It seems to exert this action by increasing the transcription of genes for glutamate cysteine ligase, the rate limiting enzyme of glutathione synthesis.
Increase biotransformation enzyme activity of phase II stimulates the elimination of potential carcinogens. Several animal studies have shown that curcumin increases the activity of phase II enzymes such as glutathione S-transferase or UDP-glucuronyl transferase.
Curcumin provides protection against the harmful effects of many chemicals.
It reverses the damage induced in liver by aflatoxin and blocks biochemical and pathological changes in liver induced by alcohol.
Thus, when treating mice with diethylnitrosamine, they usually develop liver cancer.
When treating animals with curcumin, the percentage of them develop cancer from 100% to 38% and the number of tumors fall of 81%.
Suite here:
http://ecologeeks.com/2009/02/16/curcumine-pigment-principal-du-curcuma/
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